A Review of Novel Anticoagulants

Authors

  • Jordan A. Green Division of Hematology Department of Medicine Dalhousie University Halifax, Nova Scotia
  • Stephen Couban Division of Hematology Department of Medicine Dalhousie University Halifax, Nova Scotia
  • David Anderson Division of Hematology Department of Medicine Dalhousie University Halifax, Nova Scotia
  • Sudeep Shivakumar Division of Hematology Department of Medicine Dalhousie University Halifax, Nova Scotia

DOI:

https://doi.org/10.15273/dmj.Vol39No2.3738

Abstract

The well-established indications for anticoagulant therapy include atrial fibrillation, venous thromboembolism (VTE) and mechanical heart valves. Vitamin K antagonists are the most common anticoagulants used in the outpatient setting. Two new classes of anticoagulants (direct thrombin and factor Xa inhibitors) have shown promise as alternatives to the vitamin K antagonists. Specifically, dabigatran, rivaroxaban and apixaban have been studied in comparison to warfarin for their use in preventing systemic stroke/embolism in patients with atrial fibrillation and
for managing the recurrence of VTE. This article will review the literature on the efficacy of these agents, as well as the benefits and disadvantages of their use.

Downloads

Published

2013-11-06

How to Cite

Green, J. A., Couban, S., Anderson, D., & Shivakumar, S. (2013). A Review of Novel Anticoagulants. DALHOUSIE MEDICAL JOURNAL, 39(2). https://doi.org/10.15273/dmj.Vol39No2.3738

Issue

Vol. 39 No. 2 (2013)

Section

Review

License

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).