HIV-Disease and Host Allelic Polymorphism in Long-Term Non-Progressors

Authors

  • Trevor D. Burt Harvard-MIT Division of Health Sciences and Technology Harvard Medical School Boston, Massachusetts

DOI:

https://doi.org/10.15273/dmj.Vol26No1.4419

Abstract

Since its recognition in the early 1980's, Acquired Immunodeficiency Syndrome (AIDS) has become a pandemic, and in 1997 it was estimated that 30-40 million individuals worldwide are infected with the Human Immunodeficiency Virus (HIV). While it remains an incurable and potentially devastating infection, particularly in regions where modern health care is unavailable, recent years have seen striking advances in the understanding of AIDS pathology, development of diagnostic modalities, and rational design of new treatments. Recently it has been recognized that there exists a subset of individuals who, while infected with HIV, remain asymptomatic with regard to the classical manifestations of AIDS. These individuals have been called “long-term survivors” or “long-term non-progressors” (LTNPs). Similarly, there appears to exist a subset of exposed-uninfected individuals who, while exposed to virus multiple times, remain uninfected. This article reviews the current understanding of how these individuals remain resistant to HIV progression.

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How to Cite

Burt, T. D. (1998). HIV-Disease and Host Allelic Polymorphism in Long-Term Non-Progressors. DALHOUSIE MEDICAL JOURNAL, 26(1). https://doi.org/10.15273/dmj.Vol26No1.4419

Issue

Vol. 26 No. 1 (1998)

Section

Original Research

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